When it comes to Viagra, almost everyone in the country knows what she is for! But for most people, and do not really “know” it, she only half-understood, love and hate. Love her because she can help their own “male”, to revive the masculine; hate her, because always feel dependent on her, can not leave her. These years, “Viagra” has been working hard, but like the “mistress” of the general reputation, she really is not so much? Today, let’s understand the real “Viagra”. A. What is Viagra in the end? “Viagra is the direct translation of its English name Viagra, the reason why we know “Viagra” because it was the first to enter the Chinese market, because she took the world by a blue storm (blue pills). In medical terms, it is a PDE5 inhibitor, and its scientific name is sildenafil citrate. At the beginning of sildenafil research, the goal was to apply it to the treatment of coronary heart disease, dilating the coronary arteries of the heart to treat angina pectoris. However, as the research progressed, scientists found that sildenafil was not effective in treating coronary heart disease, but accidentally discovered that it had a significant effect in dilating the cavernous blood vessels of the penis. It is this accidental discovery that has led to our current treatment of erectile dysfunction efficacy of the exact drug, in the history of erectile dysfunction treatment has the same significance as a milestone. Second, what kinds of Viagra are there? Before July 2014, there were three main PDE5 inhibitors in China, namely Viagra (sildenafil), Elidel (vardenafil), and Cialis (tadalafil). Tadalafil is a long-acting agent that lasts for a long time in the body, and because of this feature, it leads this class of drugs from “on-demand” (taken half an hour to an hour before each time you have sex) to a new level of “on-time” (taken every day on time). (taken every day, with or without sex). After July 2014, with the arrival of the patent protection period of sildenafil, the domestic Viagra – Jingo smoothly listed, followed by Wanfeile. In addition, there are a number of domestic pharmaceutical companies are currently applying for …… With the other two PDE5 inhibitors patent is about to expire, it is conceivable that in the near future, we should be able to choose the “Viagra” like a cold medicine. Third, how to take the correct “Viagra” it? 1, on-demand treatment On-demand treatment, that is, before sex, half an hour to an hour in advance to take the drug. Several of the above PDE5 inhibitors can be taken in this way. This method of taking is generally applicable to patients with mild erectile dysfunction and psychological erectile dysfunction. For patients with psychogenic erectile dysfunction, the medication can be stopped after one to several doses. Sometimes it also applies to some patients with severe erectile dysfunction, and those who have poor results with conventional treatment can take a full dose before each sexual intercourse to help erection. For patients with erectile dysfunction, severe erectile dysfunction or some patients with psychogenic erectile dysfunction who have underlying diseases (most commonly hypertension and diabetes), it is necessary to take the drug once a day and on time, which will achieve more desirable results. Currently, only tadalafil can effectively maintain the effective concentration of the drug in the body due to its unique long-acting effect. The exact duration of administration varies from person to person, but for patients with underlying medical conditions, a minimum of 3 months is generally recommended. Nowadays, the treatment of erectile dysfunction advocates personalization, so in the clinical treatment process, a considerable number of patients are on-demand and on-time combination of taking, the specific method of taking to listen to the doctor’s instructions. 3, precautions (1) the first take is not the same as the drug is not effective: clinically some patients, think the drug is quite expensive, want to save some to eat, the doctor let eat a grain, he ate half a grain, after eating no erection, the next day ran to the hospital to find a doctor, said so expensive drugs are not effective. This is not really ineffective. In the case of a sufficient amount (sildenafil 100mg, vardenafil 20mg, tadalafil 20mg), it can only be considered ineffective if it is taken more than 3~4 times in a row to effectively help erection. (2) Waiting for an erection after taking the medicine: clinically, from time to time, we encounter patients who reflect that their penis does not have an erection after taking the medicine and waiting left and right. PDE5 inhibitors must have sufficient and effective sexual stimulation after taking the drug for the penis to get an erection. (3) Pay attention to the time of sexual life: sildenafil and vardenafil can start sexual life half an hour to one hour after taking the drug, and the drug maintenance time is about 4~5 hours. If you exceed this time, it will not work. Tadalafil also needs to be taken half an hour to one hour earlier, but the drug can last for 3 days. During the effective drug time, create some joyful and relaxing atmosphere and say some love words to facilitate erection. (4) Multiple attempts can be made in a short period of time: for young newlyweds, the first time after taking the drug is unsuccessful, take a break and try again. Do not stick to the night work, the morning may have better performance. (5) Not to be taken with nitroglycerin drugs: Although the safety of these drugs is very good, if you have coronary heart disease and are taking such drugs as isosorbide mononitrate, you can not take PDE5 inhibitors. Remember, remember, remember, the important thing to say three times. (6) Side effects: Common side effects include dizziness, headache, facial flushing, nausea, and digestion without waves. Some patients may also experience muscle pain and visual abnormalities. For most patients, the symptoms that occur are mostly mild and can be tolerated. It slowly disappears as the drug is reduced. Fourth, over the years, do you have prejudice against her? 1. Is it an aphrodisiac? The word aphrodisiac, we often see from movies and TV and other works, so we have some deep-rooted bad images of it. It refers to those drugs that produce and enhance sexual desire and promote erection. Real aphrodisiacs can be simply divided into sex hormones, neuroleptics, psychedelics (drugs such as marijuana, which is illegal, remember). The main effect of PDE5 inhibitors is to dilate blood vessels, and only in the presence of sexual stimulation can make the pubic meridian engorged with blood and erection, without affecting daily life. So no matter what, it is not an aphrodisiac. By the way, alcohol is actually a very effective catalyst for sex, and “drunkenness and promiscuity” may be its true reflection. 2. Is it a sex hormone? Some people worry that PDE5 inhibitors are not hormones and have serious side effects. The hormones mentioned here mostly refer to sex hormones, for men, androgen is a very important sex hormone. It plays an important role in promoting the maturation of male sexual organs, the development of secondary sexual characteristics and the maintenance of sexual function. Androgen preparations, such as testosterone undecanoate, are indeed used in the treatment of erectile dysfunction, but PDE5 inhibitors are not hormonal drugs; they are enzyme inhibitors that increase blood flow in the cavernous body of the penis by relaxing vascular smooth muscle, resulting in erection. If you take PDE5 inhibitor as a sex hormone, how can you make the real sex hormone testosterone undecanoate embarrassed. 3.Does it have dependence? There are many patients who have this concern, including those who are taking the medication. For patients with psychological erectile dysfunction, the drug can be stopped after taking the drug and eliminating psychological barriers through several successful sex lives, so it is not possible to talk about dependence. For erectile problems caused by organic erectile dysfunction, such as hypertension and diabetes, etc. Firstly, the primary disease needs to be controlled to prevent further damage to erectile function from the primary disease. Secondly, after using PDE5 inhibitors, they need to be used continuously for at least 3-6 months, and then gradually reduced to discontinued according to the condition. Due to the prolonged and severe nature of the underlying disease, it is sometimes difficult to be completely cured by medication, and this is when long-term use is required. Please note: it is not the drug that makes you dependent, but your condition requires this drug treatment. At this point, please don’t complain, think about those patients with refractory erectile dysfunction who are still not effective on PDE5 inhibitors! At least you are taking the medication, which is a blessing among misfortunes! Please adjust your mindset. In clinical practice, some patients have a great prejudice against long-term medication, saying “I can’t rely on medication” at every turn. In fact, erectile dysfunction and hypertension, the same reason, the lesion has occurred, the need for long-term medication, as long as the reasonable use of drugs, you can control the side effects within the acceptable range, can live a good life, the main problem is the psychological unacceptable, such psychological is not conducive to the recovery of the disease. We have to rational understanding of erectile dysfunction, which is a disease, a chronic disease, is a disease requires treatment, to face frankly, “Viagra” as a common vasodilator drugs can be. 4.Is it addictive? Drug addiction, commonly known as “addiction” refers to certain drugs have a special toxicity, so that people in a special state of mind “euphoria”, a strong “craving” for the substance “The drug user is driven by this craving, “drug-seeking behavior” and frequent “drug-using behavior”. If the use of the drug is interrupted, a serious reaction will occur, called “withdrawal”. It is also characterized by recurrent, uncontrollable compulsive behaviors like those of drug users. So, are PED5 inhibitors currently addictive? So far, globally, there are no reports of addiction to three PDE5 inhibitors. Therefore, there is no need to worry about male friends. 5, sexual health stores sell a variety of “golden gun” is true First of all, the relevant regulations of the State Food and Drug Administration, PDE5 inhibitors are prescription drugs, can only be sold in hospitals and pharmacies, sexual health stores are not allowed to sell the National Drug Registration number of drugs. The sexual health stores sell a variety of “Golden Gun”, “Black Diamond” and other health products, if you take, can achieve similar PED5 inhibitor effect, then it must contain such ingredients, because there is no Chinese medicine can achieve immediate results . There is a serious problem, these supplements are not regular drugs, in the production process and the quality of drugs, it is difficult to get assurance, and each piece of medicine contains the amount of active ingredients may not be the same, so it is difficult to ensure the efficacy, and difficult to adjust the dosage, is not conducive to recovery. “Viagra is a vasodilating drug, a drug that specifically dilates the blood vessels of the penis. We need to understand it correctly, not over-apply it, and not to be prejudiced against it, so that she can escort your sexual happiness.