Concept Hand-foot syndrome is a skin toxicity side effect that can occur in tumor patients receiving chemotherapy (e.g., capecitabine-Xyloda) or molecularly targeted therapies, primarily in areas of compression, characterized by numbness, dulled sensation, abnormal sensation, tingling, painless or painful sensation, swelling or erythema of the skin, desquamation, chaffing, sclerotinia-like blisters, or severe pain. The median time to onset of hand-foot syndrome in oncology patients receiving capecitabine monotherapy was 79 days (range from 11-360 days). Grading Grade 1 hand-foot syndrome was defined as the presence of any of the following: numbness, dulled sensation/abnormal sensation, tingling sensation, erythema, and/or discomfort not interfering with normal activities of the hands and/or feet.Grade 2 hand-foot syndrome was defined as painful erythema and swelling of the hands and/or feet and/or discomfort interfering with the patient’s activities of daily living.Grade 3 hand-foot syndrome was defined as wet flakiness of the hands and/or feet, ulcers, blisters, or severe pain and/or severe discomfort that prevents the patient from working or performing daily activities. Dosage adjustment of capecitabine 1. When Grade 2 or 3 hand-foot syndrome occurs, use of capecitabine should be suspended until it returns to normal or until its severity is reduced to Grade 1. 2. When Grade 3 hand-foot syndrome occurs, the dose of capecitabine should be reduced when it is reintroduced. 3. When combining capecitabine with cisplatin, the use of vitamin B6 (pyridoxine) for symptomatic improvement or secondary prevention in the context of hand-foot syndrome is not recommended, because of reports that vitamin B6 may reduce cisplatin’s ability to improve symptoms and reduce the risk of cisplatin’s ability to reduce symptoms and secondary prevention. reported that vitamin B6 may reduce the efficacy of cisplatin. Preventive and therapeutic clinical statistics show that most patients experience only grade 1 symptoms, some patients experience grade 2 symptoms, and very few patients experience grade 3 symptoms. The occurrence of hand-foot syndrome is not terrible, as long as the following points, more can be prevented and controlled: 1, daily life as much as possible to avoid friction of the hands and feet and contact with high temperature items, such as patients do not wear tight and ill-fitting shoes, to avoid friction and pressure on the hands and feet, to avoid intense exercise and physical labor, to reduce the number of times that the hands and feet are in contact with hot water, including dishwashing and hot showers, wearing dishwashing gloves and Wearing dishwashing gloves does not reduce the damage because rubber stores heat and damages the skin of the palms.2. Using shock-absorbing insoles, wearing slippers at home, and placing the hands and feet in an elevated position while sitting or lying down can help prevent hand-foot syndrome.3. If necessary, take vitamin B6 and Cilastatin orally under the direction of a doctor.4. Keeping the skin of the hands and feet moist can help prevent and bring about an early healing of the lesions. Soak your hands and feet in warm water for 10 minutes, then wipe them dry and apply a skin cream, such as Vaseline ointment. This can effectively adsorb water on the skin. 5, avoid exposure to the sun. When hand and foot syndrome occurs, go out and apply sunscreen with a sun protection index of at least 30, and in winter sunbathing can only be done behind a sunny window.6. Avoid spicy and irritating foods.7. Apply cream containing lanolin locally to the hands and feet to alleviate flaking, ulcers, and pain in the skin.8. Use anti-fungal or antibiotic treatments under the guidance of a doctor if necessary.9. If blisters appear, have a medical professional treat the blisters. medical personnel to treat. Do not tear the skin with your hands when peeling occurs; you can use sterilized scissors to cut off the lifted part.