Blisters ruptured skin red flesh exposed usually associated with sweat herpes, eczema, herpes zoster viral infection, rupture needs to be localized, topical medication, systemic medication, phototherapy to alleviate the symptoms. 1. Sweat herpes: need to hurry with iodophor or disinfectant alcohol scrub trauma, local disinfection, will be cleaned up secretions, and keep the local dry. Combined with the infected person can be externally applied glycerine lotion, tretinoin cream. The blister rupture trauma is relatively large, feasible red light treatment. 2. Eczema: If there is a blister rupture, local fluid and other conditions, you can use boric acid solution for wet compresses, and then apply glycerine lotion convergence. In severe cases, tacrolimus ointment and pimecrolimus ointment can be used externally. 3. Herpes zoster: related to viral infection, after diagnosis, need to use glycerine lotion, keep the local dry, and then oral ribavirin, topical acyclovir ointment. When the blister ruptures with obvious pain, oral acetaminophen, ibuprofen, etc. can be taken to relieve pain. If the blister ruptures, do not touch it with your hands or rinse it directly with water to avoid secondary infection. If the above treatment does not improve, you should seek medical attention, and the medication should be used according to the doctor’s instructions, do not self-medication.