Vacuum cupping refers to the use of negative pressure inside the jar to simulate the effect of traditional fire cupping in order to prevent and treat diseases. In general, it is not recommended to use vacuum cupping to extract blisters, because the blisters may become infected, which is not good for health. Vacuum cupping blisters are caused by prolonged ischemia and hypoxia of the local tissue on the skin surface. Patients with sensitive skin, heavy dampness, and poor local circulation are usually more likely to have blisters after cupping, and such people should reduce the retention time appropriately. It is recommended to control the number of vacuum extractions and the duration of cupping according to the patient’s condition to avoid blisters on the skin surface. In addition, if blisters appear on the skin after vacuum cupping, if the blisters are small, it is recommended to wear loose, comfortable clothing to avoid local friction, and the blisters can be absorbed on their own after a period of time; if the blisters are large, it is recommended to go to the hospital in time to extract the liquid from the blisters, and then disinfect the dressing to promote recovery. If infection has occurred, anti-infection treatment with penicillin and cephalosporin antibiotics is also required under the guidance of a doctor.