Invasion of the portal vein usually requires radiofrequency treatment, implantation of particles or particle stents, radiotherapy or chemotherapy. The specific treatment method depends on the specific condition of the patient. Portal vein invasion is usually the invasion of liver cancer tumor cells into the portal vein system, forming portal vein thrombus. Portal vein invasion is a typical clinical manifestation of advanced hepatocellular carcinoma, and the natural survival time of patients is only 2.7-4 months, and the current standard treatment is systemic therapy, i.e. targeted therapy. Our guideline mostly recommends comprehensive treatment based on targeted therapy, combining surgery, radiotherapy, intervention and local perfusion therapy on the basis of targeted therapy, etc. Existing clinical research suggests that targeted combined surgery and targeted combined radiotherapy are effective! When the invasion of the portal vein is found, it is recommended that the patient should seek medical treatment in time and improve the relevant examination, and standardized treatment under the guidance of the doctor.