Down’s high risk requires prenatal diagnosis to clarify whether the fetus has any abnormalities. Down’s high risk means that the result of the screening process for Down’s syndrome risk is high risk, suggesting that the fetus has a higher probability of having a congenital chromosomal genetic disorder, and further prenatal diagnosis is needed, such as non-invasive DNA, amniocentesis, ultrasound, and so on. A high risk of Down’s syndrome indicates that the fetus has a high probability of having a congenital chromosomal disorder. However, it is not possible to fully determine which type of disorder it is, and further tests are needed to confirm the diagnosis. In the case of trisomy 21 or trisomy 18, the diagnosis can be confirmed by non-invasive DNA, amniocentesis, etc. In case of neural tube malformation, two systematic ultrasounds are required to confirm the diagnosis. If a pregnant woman finds that her fetus is at high risk for Down’s syndrome during Down’s screening, she should actively go to the hospital for further examination to clarify the type of disease the fetus is suffering from, and under the guidance of the doctor for further treatment.