Total cholesterol of 6.41 mmol/L is abnormal and is considered to be related to hypercholesterolemia and atherosclerosis, and requires medication as prescribed by the doctor. The appropriate level of total cholesterol should be <5.2mmol/L, while ≥6.2mmol/L is considered elevated. Therefore, total cholesterol of 6.41mmol/L is high and abnormal. There are many causes of total cholesterol, such as hypercholesterolemia, atherosclerosis, etc. Patients need to use drugs such as lovastatin, simvastatin, etc., to promote total cholesterol back to normal. Diabetes mellitus, hypothyroidism, nephrotic syndrome and other diseases can also lead to secondary elevation of total cholesterol, and such patients need to follow the doctor's instructions on the cause of the drug treatment, but also can use statin drugs, such as atorvastatin, resuvastatin and so on. In addition to medication, patients with total cholesterol of 6.41mmol/L should limit their intake of high cholesterol and high fat foods. It is recommended that people with total cholesterol of 6.41mmol/L undergo further detailed examination in order to clarify the disease and then follow the doctor's instructions to use medication, do not use drugs indiscriminately.