The mucosal cells that make up the stomach are not renewable cells, and they will not grow back after gastrectomy, regardless of whether it is a major resection or a complete resection, they cannot grow back after resection. After gastrectomy, the vast majority of patients will have reflux symptoms, such as heartburn, acid reflux, and even some patients will have a bitter taste in the mouth, and the patients may need to be equipped with long-term drugs to inhibit gastric acid secretion, gastrointestinal tract dynamics of the drug, and drugs to protect the gastric mucosa. Drugs to inhibit gastric acid secretion are mainly recommended at present are proton pump inhibitors, and H2 receptor antagonists can also be taken, proton pump inhibitors are mainly omeprazole, pantoprazole, etc. H2 receptor antagonists are mainly famotidine. Dynamics can be either morpholine or trimethoprim, etc. Gastric mucosal protective agent is generally recommended is magnesium aluminum carbonate or aluminum thioglycollate.