The 30-year survival rate of chronic leukemia is related to a variety of factors, usually below 10%. However, if patients are able to take reasonable treatments such as radiotherapy, targeted drugs and hematopoietic stem cell transplantation as early as possible, the 10-year survival rate can be increased from 20% to 80%, and even reach the survival time of normal people. Although there is no cure for chronic granulocytic leukemia, the progression of the disease can be controlled through standardized treatment, and the relapse rate can be reduced by combining with regular follow-up. 90% of patients with chronic granulocytic leukemia can achieve long-term survival through the use of reasonable targeted drugs such as ibrutinib, etc. Other treatments such as oral nitrogen mustard phenylbutyrate, intravenous cyclophosphamide and allogeneic hematopoietic stem cell transplantation need to be carried out under the guidance of a physician. Therefore, patients with chronic granulocytic leukemia need to follow the doctor’s instructions, maintain a positive attitude, and adhere to the treatment under the guidance of the physician.