Low sex hormone binding globulin may be due to endocrine disorders or problems with the development of sexual organs. When people do not pay attention to their lifestyle habits, it may lead to disorders in all major systems of the body, and the function of the thyroid gland may be greatly reduced, especially if they suffer from chronic liver disease or hyperthyroidism, which may cause a significant reduction in the amount of testosterone that can be used, directly affecting the low sex hormone binding globulin. The secretion of sex hormones corresponds to the continuous developmental process of the sex organs. When sex hormone binding globulin is measured to be low, it should be considered whether the sex organs are affected during development. Inadequate secretion of the pituitary gland and abnormal volume due to poor testicular development can also lead to low sex hormone binding globulin. The body’s sexual organs are closely related, and failure to take care of them during development can indirectly affect the secretion of sex hormones.