Most patients with gallstones are often accompanied by cholecystitis, endoscopic minimally invasive biliary lithotripsy often can not be completely treated, and most of them will recur after the operation, which is no longer recommended. Minimally invasive endoscopic cholecystolithotripsy can be used for simple gallbladder stones with normal gallbladder morphology, size, and function, and smooth bile inflow, and is not combined with cholecystic duct stones or bile duct stones or cholecystitis. However, most gallbladder stones are often accompanied by inflammatory lesions of the gallbladder, biliary lithotripsy can not be completely cured, often leading to recurrence of the disease or delay in the disease, the need for multiple surgeries, is not recommended. Although endoscopic minimally invasive biliary lithotripsy can maximize the preservation of the gallbladder, but whether to apply for such a method should be determined by the doctor according to the individual’s condition.