Creatinine lowering is mainly a cause-specific treatment, and there is no quick drop solution. The common causes of elevated creatinine include acute and chronic glomerulonephritis, renal failure and certain endocrine diseases, and its treatment includes general treatment, drug treatment, and dialysis and surgery if necessary. 1. Acute glomerulonephritis develops into acute kidney injury, which can cause creatinine elevation, mostly seen in hemolytic streptococcal infection, creatinine can be decreased after active drug symptomatic treatment, such as penicillin anti-hemolytic streptococcal, furosemide decongestive antihypertensive and other treatments, and dialysis needs to be active in the case of severe renal failure. In daily life, we should pay attention to rest and avoid colds. 2. The creatinine increase caused by chronic glomerulonephritis can be controlled by blood pressure, blood glucose, blood lipid, and at the same time actively intervene for clinical symptoms such as edema, anemia, and some patients can have creatinine decrease, but generally there is no rapid decrease in creatinine. 3. In renal failure, creatinine may show a continuous increase, and the treatment of disease progression to uremia stage is mainly regular dialysis. Limit the intake of sodium and potassium in daily life. 4. Certain endocrine diseases, such as acromegaly, are mainly caused by persistent overproduction of growth hormone, which can lead to increased creatinine due to increased muscle mass. The main treatment is surgery such as pituitary microadenoma resection. It can also be treated with octreotide and pegvisomant. There are various causes of elevated creatinine, it is recommended that patients should actively seek medical attention to identify the causes and standardize treatment under the guidance of doctors.