There are three aspects to consider when the hands and arms go numb at night while sleeping. The first aspect is that if the patient’s numbness in the hands and arms persists without relief, it should be considered to be caused by cerebrovascular disease. Because the cerebral blood flow is relatively slow during sleep, it may lead to the occurrence of cerebral infarction disease, and the patient will have the symptoms of numbness in the hands and arms. In this case, it is necessary to promptly visit the hospital for examination and treatment. Secondly, consider that the patient does not turn over during sleep. It may be that the body is pressurized, resulting in poor blood circulation in the pressurized hands and arms, and the symptoms of numbness. Thirdly, it is considered to be caused by cervical spondylosis. When sleeping at night, the nerve roots of the cervical spine are compressed and stimulated because of improper sleeping posture, which leads to the phenomenon of numbness in the arms. The symptoms of numbness in the hands and arms can be relieved through activities, and the patient is advised to consult an orthopedic surgeon for examination and treatment.