The “three highs” refer to high blood sugar, high blood cholesterol and high blood pressure. These three common cardiovascular enemies often work together to destroy the human cardiovascular system in a prolonged, continuous, progressive and irreversible manner. Like a city bombed by enemy planes, blood vessels damaged by high sugar, high fat and high pressure show diffuse lesions. Either the surface of the blood vessels is rough, or the lipid accumulation on the surface of the blood vessels, or the blood vessels are narrowed, or the blood vessels are occluded, or the blood vessels become hard as glass and lose elasticity. In short, when the human blood vessels suffer from “three highs”, the progress of vascular disease is significantly accelerated. Patients with three highs often end up dying from coronary heart disease or cerebrovascular accidents. The harm of three highs to the human body is not 1+1+1=3, but 1+1+1>3. Therefore, in the treatment of diabetes, lowering sugar is not an end, but a means, the ultimate goal is to protect blood vessels, so as to protect the heart, kidney, brain, eyes and other important vital organs. To break the triple alliance of hyperglycemia, hypertension and hyperlipidemia, the best offensive plan is to “attack in all aspects”, not only focusing on combating blood sugar. Data from a large number of clinical trials have shown that lowering blood pressure and blood lipids is more beneficial to the heart and brain than lowering blood sugar. The “glucose-centric” treatment plan, which assumes that controlling blood glucose is the only way to rest easy, is not correct. Regarding blood pressure lowering, it is now advocated to combine multiple drugs to lower blood pressure, and it is appropriate to control blood pressure at 130/80mmHg. According to the current view, the lower the blood pressure, the better. As long as the patient does not feel unwell, the lower the blood pressure, the lower the chance of a cardiovascular event. The elderly are a different story. It has also been suggested that all diabetic patients should take ACEI-type antihypertensive drugs, such as captopril, because they have a strong protective effect on blood vessels. But in fact, the choice of antihypertensive drugs should be based on the patient’s age, severity of complications and economic situation before deciding. With regard to lipid-lowering treatment, there is also a gradual international unification of understanding. It is now believed that patients can benefit from lipid-lowering drugs, regardless of the amount of lipid reduction, as long as they are taken. For low-risk patients, a decrease in LDL cholesterol of less than 100 mg/dL is considered to meet the standard. For high-risk patients, who are prone to cardiovascular accidents, it is recommended to lower LDL cholesterol to less than 75mg/dL. It is even suggested that all diabetic patients should take statin lipid-lowering drugs because they are very protective of blood vessels. Therefore, controlling the “three highs” has become a unified program for diabetes treatment worldwide. Here, we repeat the values of the “three highs” control target so that all diabetic patients can adjust their treatment plan according to the target achieved. Blood glucose control target: glycosylated hemoglobin <6.5%; lipid control target: LDL cholesterol <100mg/dL (that is, 2.6mmol/L); blood pressure control target: less than 130/80mmHg. These three targets are like the Big Dipper in the dark sky, guiding patients with "three highs" toward victory. patients towards the direction of victory.