Trigeminal disorders are hypertension, hyperglycemia and hyperlipidemia, which can exist alone or in association with each other. They have become the “number one killer” of humans. Among the Chinese population, deaths related to THP account for 27% of all deaths. The correct timing of medication is especially important for patients with triglycerides. A, blood pressure drugs 1 human blood pressure rhythm sunrise and sunset. In order to work and rest needs, under normal physiological conditions, human blood pressure within 24 hours is a certain rhythm fluctuations. Early in the morning, blood pressure begins to rise at 4~5 o’clock, 6~8 o’clock to reach the highest peak of the day after a steady decline; 16~18 o’clock again a small peak, followed by a slow and continuous decline, 0~2 o’clock to reach a trough and maintain until 4~5 o’clock. The rhythm of blood pressure can be divided into four types according to the decrease of blood pressure at night: ① arytenoid blood pressure: blood pressure at night is 10%-20% lower than that at daytime; ② non arytenoid blood pressure: blood pressure at night is 0-10% lower than that at daytime; ③ super arytenoid blood pressure: blood pressure at night is >20% lower than that at daytime. Blood pressure at night is >20% lower than daytime; ④ Anti-杓杓-type blood pressure: blood pressure at night is not lower or even higher than daytime level. In addition to arytenoid blood pressure, the other three patterns are all abnormal blood pressure rhythms. The arytenoid rhythm of blood pressure is beneficial in adapting to the body’s activity pattern and protecting the structure and function of the heart. Patients with non-arytenoid blood pressure rhythms are considered to be at high risk for complications of cardiovascular disease.3 Time to take medication for arytenoid hypertension Generally speaking, oral antihypertensive drugs appear 30 minutes after taking the medication, and their effects are strongest after 2 to 3 hours. In order to effectively and smoothly control blood pressure, the best antihypertensive effect is given before the peak. For patients with arytenoid hypertension, if they take long-acting antihypertensive drugs once a day, it is best to take them at 7 a.m.; if they take antihypertensive drugs twice a day, it is best to take them at 7 a.m. and 3-6 p.m. In arytenoid hypertension, antihypertensive drugs should not be taken at bedtime or at night to avoid low blood pressure (diastolic blood pressure) during sleep at night, which may lead to ischemic stroke, especially in the elderly.4 For patients with arytenoid hypertension, if they take a once-a-day long-acting antihypertensive drug, it should be taken at 8:00 p.m. This can significantly improve the patient’s arytenoid blood pressure rhythm. In contrast, taking the medication at 7:00 a.m. has a tendency to aggravate the non-ascending blood pressure rhythm. Patients with hypertension should always go to the hospital for blood pressure monitoring to find out whether they have arytenoid or non-arytenoid blood pressure, and then personalize their medication. In addition, hypertensive patients should pay attention to monitoring the changes in blood pressure at various time points after medication to prevent cardiovascular and cerebrovascular events. Second, statin lipid-lowering drugs1 Cholesterol sources and hazards Cholesterol comes from two pathways in vitro or in vivo, with the former relying on dietary intake and the latter mainly synthesized in the liver. If there is excess cholesterol in the body, it will be deposited in the walls of the arteries and produce atherosclerotic plaques, which will gradually narrow or block the lumen of the blood vessels, causing ischemia or infarction of the tissues and organs supplied with blood. 2 statin lipid-lowering drugs dosing time is currently the most widely used clinical “star” class of lipid-lowering drugs for statin lipid-lowering drugs. Such as pravastatin, simvastatin, resulvastatin, etc.. Statin lipid-lowering drugs can competitively inhibit HMG-CoA reductase, a key enzyme in hepatic cholesterol synthesis. Because the liver synthesizes cholesterol most actively at 2 to 3 at night, statin lipid-lowering drugs should be taken before bedtime. Atorvastatin and Rosuvastatin have a long half-life and can be given once a day at any time of the day.3 Combination of statins and beta-lipid-lowering agents Statin lipid-lowering agents, such as those combined with beta-lipid (mainly gemfibrozil) for the treatment of mixed hyperlipidemia, should be taken in order to avoid adverse effects such as hepatic enzyme metabolism, rhabdomyolysis and myalgia due to competing hepatic enzyme interactions. It should be taken alternately in the morning, evening or between days. Third, the time of taking oral hypoglycemic drugs hypoglycemic drugs, mainly related to the type of hypoglycemic drugs and meal times, must not be generalized. The wrong time to take the drug, not only can not achieve the ideal effect of lowering blood sugar, but also cause hypoglycemia and other adverse reactions. The main function of insulin-producing agents is to stimulate the pancreatic β-cells to secrete insulin, but the prerequisite is that the pancreatic β-cells still have certain functions of synthesizing and secreting insulin. Commonly used sulfonylurea hypoglycemic drugs are: glipizide, gliclazide, glipizide, glimepiride, etc. These drugs can cause severe hypoglycemic reactions and need to be taken within 20~30 minutes before meals. The commonly used non-sulfonylurea insulin-producing drugs are: Repaglinide and Naglinide. They are usually taken within 0~15 minutes before meal as the insulin-producing reaction occurs within 30 minutes after oral administration.2 Insulin sensitizers This class of drugs can increase the sensitivity of tissues to insulin, reduce insulin resistance and protect pancreatic function. However, there is a risk of causing or aggravating congestive heart failure in some patients. Commonly used insulin sensitizers are: pioglitazone and pergolide. This class of drugs when applied alone does not occur hypoglycemic reactions, taking the drug is not related to eating. 3 Metformin Metformin not only can lower blood sugar, but also can improve insulin resistance and lipid metabolism, make weight loss, prolong life and reduce the rate of disability and morbidity and mortality. Metformin enteric tablets: 0.25g-0.5g/time, 2-3 times/day, daily dose: 1-1.5g, max 2g; take with meal or after meal. Metformin extended-release tablets: the starting dosage is usually 0.5g once daily, taken with dinner; the maximum daily dose should not exceed 2g. If satisfactory efficacy cannot be achieved with 2g once daily, it can be changed to 1g twice daily, taken with or after meals. 4 alpha-glucosidase inhibitors commonly used alpha-glucosidase inhibitors are: acarbose, voglibose. These drugs compete with carbohydrates in food for carbohydrate hydrolase and inhibit the conversion of disaccharides to monosaccharides, thus slowing down the production of glucose and delaying its absorption.