The six sex hormones reflect ovarian hormone secretion and pituitary function. Estradiol is an indicator to monitor female estrogen levels, and a low test value may indicate abnormal ovarian or pituitary function. The basal hormone level of women is tested on the 3rd day of menstruation and the luteinizing function is tested 1 week before the next menstruation. However, a low estradiol level alone is usually not diagnostic of the disease, which can occur during menopause or at some point during a woman’s physiological period. Therefore, the test results need to be analyzed in combination with physical signs and other laboratory tests. If the test only reveals low estradiol and there are no other specific signs, it may be related to individual differences, bad emotions, testing errors, etc. You can follow up the sex hormone test regularly and observe. 1. Pituitary disorders: If estradiol is low and follicle stimulating hormone and luteinizing hormone are also low, this may indicate hypopituitarism, and a pituitary MRI is needed to rule out pituitary disorders. Pituitary gland abnormalities can occur when the thyroid, adrenal glands and other target organs do not receive enough information and become hyper- or hypo-functional, which generally requires hormone replacement therapy. 2. Ovarian ultrasound can check ovarian lesions. At this time, women may have a combination of irregular menstruation, infertility, amenorrhea, thinning hair, acne, and slow growth and development, which need to be treated for ovarian diseases. Estrogen replacement therapy can be used clinically. Under the guidance of a doctor, estrogenic drugs such as estradiol valerate and nil estrol can be taken orally, and progesterone and other progestin drugs can be used. In daily life, women can prevent it by paying attention to a balanced diet, regular exercise habits, and effective vitamin D and calcium supplementation.