A painful lump in the lower eyelid may be caused by, among other things, a granuloma. Granuloma, also known as blepharitis, is usually an acute bacterial infection caused by not paying attention to eye hygiene, and the common causative organisms are staphylococcus, especially Staphylococcus aureus. Patients may present with symptoms such as localized redness, swelling, heat and pain in the eyelids, and hard nodules can be touched under the skin. Early granuloma can be localized hot compresses to promote the inflammation to subside. Antibiotics can also be used under the guidance of the doctor, commonly used are levofloxacin eye drops and so on. When the abscess is formed, you need to go to the hospital for incision and drainage of pus. Patients with painful bumps in the lower eyelid should seek timely medical attention and follow the doctor’s instructions according to the results of the examination.