Children’s antipyretic drugs do not exist the safest statement, currently recognized as safer and most commonly used antipyretic drugs for ibuprofen, acetaminophen, need to pay attention to the contraindications to the use of drugs, antipyretic drugs need to be used under the guidance of a doctor. Fever is a common symptom in pediatrics, can be seen in a variety of diseases, in the course of the disease, elevated body temperature can be caused by increased respiratory rate, heart rate, muscle pain and general malaise and other discomforts, the rational use of antipyretic drugs is very important to relieve the discomfort of children with fever. Currently recognized as safer antipyretics are ibuprofen, acetaminophen, etc., the use of which should be rationalized under the guidance of a physician according to the child’s age, body weight, and the presence of specific diseases in order to achieve safe results. If children with bleeding disorders develop fever, the pros and cons should be weighed in the context of their condition. Acetaminophen and other medications that have less impact on coagulation can be used under the guidance of a physician’s evaluation to reduce fever. Ibuprofen is generally not used for fever in children with gastrointestinal disorders or cardiac insufficiency, and acetaminophen may be used as directed by a physician when necessary. It is recommended that you seek medical attention and use antipyretic medications under the direction of a physician.