There are more kinds of pigmentation spots. When treating pigmentation spots, we must first distinguish the types of spots, so that we can target and prescribe the right medicine to get the ideal effect of removing spots. 1.Nevus of Ota Diagnostic criteria: occurring in the sclera and trigeminal nerve asymmetrically distributed, most of them are patch-like, a few are spot-like, varying in size, cyan, brown, blue, greenish black, 50% of patients have onset in adolescence, mostly women, unrelated to sunlight, season and endocrine, no conscious symptoms, self-healing tendency, most of them do not bulge the skin, but may bulge the skin with age, the area increases and the color worsens. 2.Ito nevus Diagnostic criteria: occurring in the deltoid muscle of shoulder peak and the proximal end of upper limbs, patch-like, light brown, blue, cyan, greenish black, not related to age, gender, family history, sun exposure, season, endocrine, no conscious symptoms, no tendency of self-healing, not elevated or sunken in the skin, no change in color with increasing age. 3.Zygomatic brown nevus Diagnostic criteria: symmetrical distribution on the zygomatic area, occasionally on the eyelids, nose, spot-like, round or oval, 1-5mm in diameter, dark gray, dark brown, gray-brown, brown, 16-40 years old female, some patients have family history unrelated to sun exposure, season, endocrine, no conscious symptoms, no tendency of self-healing, no elevation or depression in the skin, color of the pigmentation slowly increases with age. Most of them have pigmentation after combined inflammation. 4.Mongolian spot Diagnostic criteria: It can develop in any part of the body, mostly in the lumbosacral area and buttocks, ranging from a few square centimeters to dozens of square centimeters, with blue, cyan and brown patches. It is present at birth, mainly occurs in yellow children, has nothing to do with sunlight, season and endocrine, has no conscious symptoms, can heal by itself, does not bulge or sink into the skin, and fades naturally with age. 5.Pigmented nevus Diagnostic criteria: Junctional nevus: brown, cyan, black spot-like pigmentation with different shades from a few millimeters to a few centimeters in diameter, smooth and hairless, but can also be slightly elevated, and can occur on any part of the body, with no difference in the incidence of gender. Mixed nevus: Clinical presentation is similar to junctional nevus but more elevated on the skin. Intradermal nevus: Varies from a few millimeters to several centimeters in diameter. They occur on any part of the body and are more common on the head and neck. The color is brown, cyanotic, black or skin-colored. Less than 25px in diameter, with hairy surface. It is hemispherically elevated and papilloma-like with tipped damage. No self-conscious symptoms, no tendency to self-heal. 6.Post-inflammatory hyperpigmentation Diagnostic criteria: occurrence of inflammatory sites, flaky, dotted, brown, tan, black, family history, related to sun exposure, season, no conscious symptoms, tendency to self-heal, not elevated or sunken in the skin, with age and time discoloration fades or disappears. 7.Seborrheic keratosis Diagnostic criteria: occurring in any part, head, face, trunk and upper limbs are the most common, brown, black, dark brown, spots, patch-like, older people over 50 years old. Related to sunlight and season, no conscious symptoms, no tendency of self-healing, some of them will slightly raise the skin, and the color of pigmentation slowly increases with age. 8.Coffee spots Diagnostic criteria: occurring in any part of the body, patchy coffee color, onset at birth or in early childhood, unrelated to sunlight, season and endocrine, no conscious symptoms, no tendency of self-healing, not elevated or sunken in the skin, increasing in number as the area increases with age. 9.Plaque nevus Diagnostic criteria: occurring in all parts of the body, more on the trunk, generally asymmetric, patches, several millimeters in size, brown or dark brown papules scattered on light brown patches, at birth or in early childhood, unrelated to sun exposure, season, endocrine, no conscious symptoms, no tendency to self-heal, slightly elevated on the skin. The development is faster in adolescence and no longer expands in adulthood. 10.Chloasma Diagnostic criteria: symmetrically distributed yellow-brown spots or patch-like pigmentation on cheeks or forehead, related to gender, with certain family history, related to sun exposure, season and endocrine, with tendency of self-healing, not elevated or sunken in the skin, and may fade or disappear with time. 11, melanosis Diagnostic criteria: occurring in exposed areas, facial, temporal, jaw, chest, back of the hand spots or patches of brown, blue-gray, pigmented spots surrounded by hair follicle lesions, more women than men, related to seasonal sun exposure, with a tendency to self-healing, but not obvious, not bulging or sunken in the skin, out of contact with the source or sun discoloration may be reduced. 12.Black spots Diagnostic criteria: yellowish brown or dark brown spots on any part of the body, occurring at an early age, some at birth, not related to sunlight, season or endocrine, no conscious symptoms, no tendency of self-healing, not elevated or sunken in the skin, increasing in number with age, stable or gradually decreasing in adulthood. 13.Freckles Diagnostic criteria: occurring on sunburned area, yellow-brown spot-like, onset at 5-10 years old, related to sunburn and season, no conscious symptoms, no tendency of self-healing, not elevated or depressed in the skin, the number of spots increases with age. 14.Blue nevus Diagnostic criteria: Common blue nevus and cellular blue nevus. Common blue nevus: It occurs on upper limbs and face, spot, 1-8mm, gray-blue, develops in early childhood, not related to sunlight, season and endocrine, no conscious symptoms, no tendency of self-healing, elevated on skin, color will increase with age, no more growth until about 8mm, no malignant change for life. Cellular blue nevus: occurring in the buttocks, coccyx, compared to the ordinary blue nevus larger, blue, blue-brown, at birth that is, easy to malign into melanoma. 15, tattoo Diagnostic criteria: a variety of pigments pierced or due to trauma into the skin painted with different images, over time, the color may fade.