When toothache produces headache, you can choose to take oral analgesic drugs, such as acetaminophen or loxoprofen sodium, etc. At the same time, you can take appropriate oral anti-inflammatory drugs, you can use cephalosporin plus metronidazole tablets. If the cephalosporin allergy can choose roxithromycin, plus metronidazole or ornidazole tablets, can effectively play the role of pain relief and anti-inflammatory, if the pain can not be relieved or have treatment conditions can promptly go to the stomatology department. Usually, after the pulp is opened, the nerve-killing drug or the nerve is removed to quickly relieve the headache of the toothache. In addition, it is recommended to take a film to check whether it is due to caries or whether the teeth have diseases, such as tooth fracture, or the phenomenon of wisdom tooth eruption, and this situation should be treated symptomatically.