Chronic gonorrhea requires more than 2 months of treatment to break the root of the disease, and in a few cases, it may persist for a long time, requiring timely adjustment of the treatment program. The disease is caused by the prolongation of acute gonorrhea and is characterized by symptoms of urethral irritation and urethral discharge in men, with the majority of women experiencing milder symptoms. A report of 567 cases of chronic gonorrhea indicated that the clinical cure rate of the disease (i.e., what is usually called “eradication”) was 83.77%, of which all recovered patients needed more than 2 months to be treated for eradication, with 36.68% of the patients being treated for eradication in 2 months, and 25.40% of the patients being treated for eradication in 3 to 6 months. The duration of the disease is related to the standardization of treatment and bacterial resistance. Once diagnosed with chronic gonorrhea should be standardized treatment under the guidance of a professional physician, such as the case of prolonged treatment should be promptly adjusted according to the drug sensitivity test anti-infection program. At the same time, avoid blindly listening to false advertisements, improve the awareness of sexual safety, refuse unclean sex.