Uncomfortable urination with anal discomfort and normal routine urinalysis are considered to be caused by interstitial cystitis, overactive bladder disease, non-bacterial prostatitis and other causes. 1. Interstitial cystitis: the pathogenesis is not clear, and is considered to be related to epithelial permeability changes, infection, mast cell infiltration and other factors. Patients often appear urinary frequency, urinary urgency, urinary pain and other symptoms of bladder irritation, and will also be accompanied by suprapubic pain, urethral pain, and so on, so that there will also be urinary discomfort with anal discomfort. At the same time, patients in the urine routine examination, will show normal stones, and need to exclude a variety of other causes to confirm the diagnosis. 2. Overactive bladder syndrome: the cause of the disease is not clear, mostly considered to be related to the nerve center and nerve transmission abnormalities, abnormal urinary habits, urinary function underdevelopment or degeneration and so on. Patients often experience symptoms such as frequent urination, urinary urgency, increased nocturia, etc., which may also be accompanied by suprapubic or perineal pain, and may also be manifested as urinary discomfort accompanied by anal discomfort. At the same time, the patient may also appear urinalysis symptoms, need to be combined with imaging, urodynamic examination, etc. for comprehensive judgment. 3. Non-bacterial prostatitis: the cause of the disease is more recurrent, and is considered to be caused by a combination of factors such as urinary dysfunction, mental psychology, and abnormal immune response. Patients often have pain in the pelvic region, such as the perianal area, penis, perineum, etc., and there is no abnormality in the routine urinalysis. It is recommended that after the appearance of the above phenomena, patients should clarify the cause of the disease in a timely manner and carry out targeted treatment under the guidance of doctors.