For couples planning to get pregnant should make the following preparations: 1, 3-6 months in advance to do pre-pregnancy checkups, in the examination if found to be suffering from some of the diseases affecting pregnancy, should be treated in a timely manner before considering pregnancy; 2, half a year in advance to change the bad habits, couples need to quit smoking, quit drinking, avoid staying up too late to avoid the X-ray and other radiation; 3, 3 months in advance of the supplemental folic acid. Folic acid should be supplemented from three months before pregnancy, to the first three months of pregnancy, daily supplemental folic acid 0.4-0.8mg, both spouses need to supplement the service; 4, adjust the dietary structure, the diet needs to be regular, balanced, eat more protein-rich foods, fresh fruits and vegetables, less processed foods and junk food; 5, relax, moderate exercise, the body adjusted to the best state before pregnancy.