Alzheimer’s disease is a chronic disease of the central nervous system, which cannot be tested by answering questions, but needs to be derived from the combination of medical history, clinical manifestations, examination, and differential diagnosis.
1. Medical history: history of cognitive impairment, mild memory or attention loss before the onset of the disease.
2. Clinical manifestations: with the progression of the disease, there is loss of memory for recent events, logical thinking, visual-spatial impairment, irritability, and in severe cases, loss of speech, crying and laughing.
3. Examination: blood, urine, blood biochemistry tests are normal in laboratory examination, cerebrospinal fluid examination has Aβ42 decreased, EEG is decreased in wave amplitude and slowed down in alpha rhythm in early stage, CT can see enlarged ventricles and brain atrophy, MRI can see temporal lobe and hippocampus atrophy, SPECT perfusion imaging can see hippocampal blood flow and metabolism decreased, and cognitive function decline is seen in neuropsychological examination office.
4. Differential diagnosis: exclude vascular dementia, hydrocephalus, infection, metabolic and other diseases.
When Alzheimer’s disease manifestations are found, it is necessary to go to regular hospitals for consultation and treatment under the guidance of professional doctors to avoid delaying the condition.