Chronic inflammation is divided into local inflammation and systemic inflammation. Local inflammation is mainly redness, swelling, heat, pain, and dysfunction. Redness is due to congestion within the inflammatory lesion, swelling is mainly due to exudate, especially inflammatory edema, and in chronic severe cases tissue and cell proliferation can also cause local swelling, heat is due to arterial congestion and enhanced metabolism, and pain causes severe local pain related to a variety of factors, the aggregation of potassium and hydrogen ions within the local inflammatory lesion, especially inflammatory mediators, such as prostaglandins, stimulate the cause of pain related. Dysfunction, such as degeneration and necrosis of parenchymal cells within severe foci, abnormal metabolic function, mechanical compression and obstruction caused by inflammatory exudates, etc., can trigger inflammatory organ dysfunction, and inflammatory lesions are mainly localized. However, local lesions and the whole interact with each other, and more severe inflammation often shows systemic symptoms: i. leukocytosis; ii. fever; iii. mononuclear phagocyte system, cellular hyperplasia; iv. lesions of parenchymal organs.