Hepatocyte regeneration typically takes 90 days, or about 3 months. Hepatocyte regeneration refers to the rapid regeneration of new cells along the liver cytoskeleton to maintain the integrity of the liver after hepatocyte damage or partial hepatectomy. Under normal circumstances, when hepatocytes are damaged, apoptotic, or partially hepatectomized by surgery, the regeneration of hepatocytes can be accomplished through the process of hepatocyte division and proliferation, which usually takes about 90 days. If there is an underlying liver disease, such as hepatitis, cirrhosis or even liver cancer, due to factors such as disorders in the body’s internal environment or infections, the regeneration of hepatocytes will be prolonged accordingly, and may take up to 180 days, or about 6 months. In addition, if liver damage is severe and extensive necrosis occurs, which exceeds the compensatory capacity of liver cells, liver failure will occur. In order to detect liver disease in time, it is recommended to have regular and proper medical checkups and early and regular treatment when detected.