Clinically there is no “leg cramps take what medicine is best”, usually need to be treated according to different causes, the common causes are calcium deficiency, cold, overexertion and systemic diseases caused by calcium and magnesium supplements, warmth, warm compresses, or pain relievers and antispasmodic analgesic drugs and so on. 1. Calcium deficiency: For leg cramps caused by calcium deficiency, calcium supplementation is effective, such as high calcium tablets, vitamin D and so on. For other types of leg cramps, such as sports-related leg cramps, nighttime leg cramps, and leg cramps during pregnancy, calcium supplementation is not effective. 2. Cold: Patients with leg cramps caused by cold need to keep warm in time and do not continue to let their legs get cold, which will aggravate their condition. It is recommended that patients increase clothing to keep warm to prevent the legs from getting cold, and no special treatment is needed. 3. Excessive exertion: when the patient’s exercise is too large, the leg muscles will be tense and pressurized to make the leg soothing, easy to cause leg cramps, if the symptoms are light patients can massage the legs, relieve the symptoms; if the leg cramps are still residual pain after the acute onset of cramps, pain medication can be used to control the pain, common pain medications are acetaminophen, ibuprofen and acetylsalicylic acid, etc.. 4. Systemic diseases: If the patient is due to disease factors such as high fever, epilepsy, tetanus and other causes of muscle spasms, available phenytoin sodium, diazepam, chlorpromazine and other antispasmodic and sedative drugs to control spasms, but also need to be taken for different causes of appropriate treatment. There are other reasons for the performance of leg cramps, patients should go to the hospital in a timely manner to identify the cause of the disease, so as not to delay the condition.