The term “Hashimoto” generally refers to Hashimoto’s thyroiditis, short for hypothyroidism. When Hashimoto’s thyroiditis causes hypothyroidism, it may manifest as thinning and drying of the hair. Pemphigus vulgaris is a psychogenic-driven, autoimmune-related, non-scarring hair loss disorder. Patients with Hashimoto’s hypothyroidism who develop patchy baldness should be treated with levothyroxine and topical capsicum tincture for patchy baldness as prescribed by the doctor. 1. Taking levothyroxine: levothyroxine can treat Hashimoto’s hypothyroidism. It is contraindicated in patients with allergy to the drug, recent myocardial infarction and non-hypothyroid heart failure. Adverse drug reactions include palpitations, excessive sweating, weight loss and insomnia. 2. Local drug therapy: Minoxidil solution and chili tincture local application can improve local circulation, promote hair growth. There is no obvious contraindication except for allergic patients. 3. Systemic medication: cystine, calcium pantothenate, vitamin B can help hair growth, and oral prednisone can be taken for rapid and extensive hair loss. Adverse reactions such as nausea, vomiting, abdominal distension, diarrhea, etc. may occur when taking these medications, and the medication should be used according to the doctor’s instructions. 4. Phototherapy: Long-wave ultraviolet light, photodynamic therapy and low-energy lasers have certain therapeutic effects. Usually, Hashimoto’s hypothyroidism does not lead to baldness, baldness may be caused by other reasons, it is recommended that patients with Hashimoto’s hypothyroidism actively go to the hospital, according to the doctor’s guidance and advice to choose the appropriate drug treatment.