Vaginal pain in older women may be caused by atrophic vaginitis and urinary tract infection, which can be treated by using estrogen, antibiotics and other drugs. Postmenopausal elderly women have lower estrogen levels, vaginal wall atrophy, reduced local resistance, and are prone to bacterial infections, which can lead to symptoms of vaginal pain. At this time, the patient can follow the doctor’s instructions to use estrogenic drugs such as local application of estriol ointment, or oral tibolone and other treatments, combined with bacterial infections can also be used norfloxacin preparation, metronidazole and other treatments. If the elderly women appear vaginal pain at the same time, also accompanied by frequent urination, urinary urgency, urinary pain and other uncomfortable symptoms, most suggest that the patient has a urinary tract infection. At this time, the patient can follow the doctor’s instructions to use cefaclor, ofloxacin and other antibiotics for treatment. If older women have symptoms of vaginal pain, it is recommended to go to the hospital in a timely manner, improve the examination to determine the cause of the disease, and then give targeted treatment or standardized treatment.