The generic name of Sage is methimazole, which is one of the most commonly used drugs to treat hyperthyroidism. However, Sage may cause liver damage and elevated transaminases during the treatment of hyperthyroidism. If the aminotransferase does not rise more than twice the normal value, you can continue to use Sage with additional liver-protective drugs, but monitor liver function closely and continue treatment if the aminotransferase falls again. If the aminotransferase rises further and exceeds twice the normal value, it is necessary to discontinue Sage and consider iodine 131 to treat hyperthyroidism when liver function returns to normal. Switching to propylthiouracil is not recommended because propylthiouracil has a higher potential to cause liver function damage than cytarabine.