The difference between cranial endogenous osteoma and brain tumor lies in the pathogenesis, clinical manifestations and treatment. 1. Pathogenesis: There is no clear pathogenesis of cranial endogenous osteoma, and it may be related to trauma. The main causes of brain tumor are ionizing radiation and differentiation and growth of cells or tissues left over from embryonic development of the brain into brain tumor. 2. Clinical manifestations: endogenous osteoma of skull is a benign tumor, and its clinical manifestations often include localized mass, headache, dizziness, high cranial pressure, protruding eyeballs and limited neurological dysfunction, etc. Brain tumors can be malignant tumors, while brain tumors can be malignant tumors. On the other hand, brain tumors can be malignant tumors, manifesting as headache, vomiting, neurological deficits, epilepsy, vision loss, eyelid ptosis, and ocular motility disorders. 3. Treatment: endogenous osteoma of skull is benign tumor, which can be followed up by regular examination when there is no obvious symptom. If the brain tumor is malignant, it should be surgically resected once found to reduce the risk of expansion and metastasis. It is recommended to consult the doctor in time for clear diagnosis and standardized treatment according to the doctor’s prescription.