Reconceptualizing Celiac Disease

Celiac disease is not positive celiac disease Celiac disease is a frequent and common disease in women. Literature reports that its incidence is as high as 40-60% in married women of childbearing age. The female cervix is divided into the internal and external orifices. The endocervical epithelium is a slender, mucus-secreting, red columnar cell, and the exocervix is covered by a grayish-yellow squamous epithelium. Under certain factors, the squamous epithelium of the outer opening of the uterine cervix becomes covered by the columnar epithelium and celiac disease is formed. Colposcopic observation of the surface of the erosion, in fact, complete columnar epithelium, because the columnar epithelium is a single layer, the mesenchymal stroma underneath is red, so the naked eye observation of the red erosion-like. This shows that cervical erosion is not really erosion, compared with the normal smooth cervix, just intuitively feel like erosion. This change is related to the displacement of the cervical squamous and columnar epithelial junction. The cervical “erosion” observed colposcopically is an area of squamous-columnar junctional transformation. The reason why many women are so afraid of this disease is largely because they are frightened by the word “celiac disease”. Celiac disease is often asymptomatic and many women are accidentally found to have celiac disease during a normal medical checkup without any previous symptoms. Why is this? This is because celiac disease itself is not inflammation, that is, not the pathological sense of epithelial loss and inflammatory reaction, but the cervical columnar epithelium ectopic, is one of the physiological changes of the cervix, not pathological changes. When there is no pathogenic microbial infection, i.e., when there is no inflammation, patients with celiac disease may have no clinical symptoms, or only show increased secretions. Some patients may have bloody leukorrhea or bleeding after intercourse. There are also some patients with more severe symptoms, and may also have symptoms such as back pain, vulvar and vaginal itching. However, this is not due to celiac disease itself, but mostly due to combined inflammatory infections. Sex is not a direct cause of celiac disease. At present, about the real cause of cervical celiac disease is not clear, it is generally believed that mechanical stimulation or injury after marriage, such as childbirth, abortion or sex life is too frequent, can cause varying degrees of cervical squamous epithelial destruction, cervical local resistance is reduced, easy to cause cervical inflammation. However, clinical findings, no sex life of women, there is still cervical erosion, sometimes even severe erosion. This shows that sexual life is not the culprit that leads to celiac disease. At the same time, experts remind unmarried, or sexually inactive women, if there is a persistent increase in leukorrhea, or accompanied by changes in color and texture, should also be timely to the gynecological clinic, in order to identify the cause, timely treatment. Celiac disease does not necessarily lead to infertility. For women who are planning to get pregnant, if celiac disease is not accompanied by any symptoms, they should actively try to get pregnant without rushing to do too much treatment for celiac disease. If excessive leukorrhea or yellowing of the leukorrhea has caused discomfort, it can be treated with appropriate medication and pregnancy can be attempted after the symptoms improve. Is vaginal douching helpful in treating celiac disease? The surface of female vaginal mucosa is squamous epithelium, which is affected by female sex hormones and undergoes periodic shedding, which has a protective effect. At the same time, squamous epithelial cells can secrete glycogen, which is broken down into lactic acid by the lactobacillus bacteria parasitized in the vagina, thus maintaining an acidic environment in the vagina and inhibiting the growth and reproduction of bacteria. Under normal circumstances, it is not recommended that women do excessive vaginal douching, which is not beneficial to maintaining the acidic environment of the vagina, but will lead to bacterial imbalance, which can lead to vaginal inflammation. Celiac disease is not caused by bacterial infection, if the application of disinfectant, antiseptic, antipruritic, anti-inflammatory lotion to douche the vagina, may destroy the protective barrier of the vagina itself, not only is not beneficial to the celiac disease, but also may cause secondary infection of the vagina. Therefore, if celiac disease is not accompanied by vaginal inflammation, do not advocate the application of local vaginal douche. Can celiac disease be cured? At present, the most widely used method for treating celiac disease in China is physiotherapy. It is often believed that physiotherapy can cure celiac disease in one go. In fact, in the absence of a clear cause, no matter what kind of conservative treatment, it is impossible to completely cure celiac disease. Clinically, it is often encountered that after physical therapy for celiac disease, the erosion area becomes smooth, but after a period of time, celiac disease reappears. The reason for this is that no matter whether you apply microwave, iron, laser or freezing methods, the principle is to destroy the columnar epithelium on the surface of the erosion, so that it is necrotic, scabbing off, and the newborn squamous epithelium grows in, so that it can be “cured”. If the real cause of the disease is not removed, celiac disease may occur again. Should I treat my celiac disease or not? In recent years, there have been some new concepts in the academic world regarding the treatment of celiac disease. When there is no pathogenic microbial infection, celiac disease may have no clinical symptoms, or only show increased secretions, and does not need to be treated. (1) <30 years old, for simple, superficial erosion is mostly physiological changes, no special treatment. (2) >30 years old, or granular erosion, asymmetric erosion, with contact bleeding, cervical hardness is different, should be cervical lesion three-step screening, except cervical lesions. (3) Granular or papillary erosion should be treated if combined with inflammatory symptoms such as increased leukorrhea and vulvovaginal itching. If cervical cancer is excluded, physiotherapy is often advocated. (4) There are many methods of physical therapy, but the principle of treatment is the same and the efficacy is similar. The key is to grasp the correct indications, standardize the operation and pay attention to the treatment period. Does physiotherapy have any effect on pregnancy and delivery in the future? Treatment with physical methods such as laser may cause slight damage to the cervix, which may affect the dilatability of the cervix during labor and delivery in the future. It is best to go to the hospital for a checkup before you plan to get pregnant. If the celiac disease does not affect your pregnancy or is not associated with an acute infection, you can get pregnant first, and then undergo laser treatment after delivery. However, if your condition requires it, you should still follow your doctor’s advice and actively cooperate with the treatment. In principle, physical therapy only destroys a layer of cells on the surface of the cervix, and through damage repair, the columnar epithelial cells are transformed into squamous epithelial cells, thus treating cervical erosion, so physical therapy will not lead to narrowing of the cervical opening, not to mention infertility.