Reconceptualizing Celiac Disease

Celiac disease is a problem that bothers many women, and its incidence is as high as 40% to 60% among married women of childbearing age. A woman’s cervix is divided into an endocervix and an ectocervix. The endocervical epithelium is a slender, mucus-secreting red columnar cell, and the exocervix is covered by squamous epithelium. Under certain factors, the squamous epithelium of the outer opening of the cervix becomes covered by the columnar epithelium and celiac disease is formed. When the surface of the erosion is observed under colposcopy, it is actually a complete columnar epithelium, because the columnar epithelium is a single layer, and the mesenchyme underneath is red in color, so it is observed as a red erosion with the naked eye. Therefore, cervical erosion is not really erosion, just intuitively feel like erosion. This change is related to the displacement of the cervical squamous epithelium and columnar epithelium junction. Colposcopic observation of the cervical “celiac disease” is the squamous-columnar junction transformation area. The reason why many women are so afraid of this disease is largely because they are frightened by the word “celiac disease”. Celiac disease is often asymptomatic Many women are found to have celiac disease during a normal physical examination, but do not have any symptoms. This is because celiac disease itself is not inflammation, but the cervical columnar epithelium ectopic, is one of the physiological changes of the cervix, not pathological changes. When there is no pathogenic microbial infection, i.e. not combined with inflammation, patients with celiac disease may have no clinical symptoms, or only show increased secretions. Some patients may have bloody leukorrhea or bleeding after intercourse. Of course, there are some patients with more severe symptoms, in addition to abnormal leukorrhea, there may also be back pain, vulvar and vaginal itching and other symptoms. However, this is not due to celiac disease itself, but mostly due to the combined inflammatory infection. Sex is not the direct cause of celiac disease Some people believe that celiac disease is caused by sex, so once diagnosed with celiac disease, they are quite rejected to have sex. In fact, this view is wrong. At present, the real etiology of cervical celiac disease is still not clear, it is generally believed that mechanical stimulation or injury after marriage, such as childbirth, abortion or too frequent sex life, can cause different degrees of cervical squamous epithelial destruction, cervical local resistance is reduced, easy to cause cervical inflammation. However, clinical findings, no sex life of women, there is still cervical erosion, sometimes even severe erosion. This shows that sexual life is not the culprit of celiac disease. At the same time, experts remind unmarried, or sexually inactive women, if there is a persistent increase in leukorrhea, or accompanied by changes in color and texture, should also be timely to the gynecological clinic, in order to identify the cause, timely treatment. Celiac disease does not necessarily lead to infertility In the past, it was believed that celiac disease is often accompanied by inflammation, and the inflammatory cells will phagocytosis of sperm, but also lead to a change in the nature of cervical mucus, which prevents sperm from penetrating the cervical mucus to reach the uterine cavity. As the sperm cannot reach the uterine cavity successfully, it naturally fails to meet the egg, and conception is not possible. However, it is now found that in more young women, celiac disease is only a change in the type of cervical epithelial cells and is not associated with an inflammatory infection, and therefore does not lead to infertility. For women who are ready to get pregnant, if celiac disease is not accompanied by any symptoms, fertility experts recommend that they should actively try to get pregnant without rushing to do much treatment for celiac disease. If there is excessive leukorrhea or yellowing of the leukorrhea that is causing discomfort, it can be treated with appropriate medication and pregnancy can be attempted after the symptoms improve. Celiac disease has nothing to do with cancer Many women with celiac disease are worried about cervical cancer, believing that the heavier and longer the celiac disease is, the more likely it is to develop cervical cancer. Theoretically, celiac disease is a pathological change rather than true erosion. Cervical cancer, on the other hand, is an abnormal change in the squamous epithelium of the cervix, mainly due to human papillomavirus (HPV) infection. The two have different causes and pathogenesis, and different pathologic changes. Therefore, simple cervical erosion, if not combined with HPV infection, does not lead to the occurrence of cervical cancer. However, women with celiac disease should be reminded that during gynecological examination, cervical exfoliative cytology should be performed to preliminarily exclude the possibility of cervical cancer. Because it is difficult to distinguish early cervical cancer from celiac disease during gynecological examination alone. If possible, HPV test should be performed at the same time of cervical exfoliative cytology to exclude the possibility of cervical cancer and precancerous lesions. Is vaginal douching helpful in treating celiac disease The surface of the vaginal mucosa is squamous epithelium, which is affected by female sex hormones and undergoes cyclic shedding, which has a protective effect. At the same time, squamous epithelial cells can secrete glycogen, which is broken down into lactic acid by the lactobacillus bacteria that live in the vagina, thus maintaining an acidic environment in the vagina and inhibiting the growth and reproduction of bacteria. Under normal circumstances, it is not recommended that women do excessive vaginal douching, which is not beneficial to maintaining the acidic environment of the vagina, but will lead to bacterial imbalance, which can lead to vaginal inflammation. Celiac disease is not caused by bacterial infection, if the application of disinfectant, antiseptic, antipruritic, anti-inflammatory type of lotion to douche the vagina, may destroy the vagina’s own protective barrier, not only is not beneficial to the celiac disease, but also may cause secondary infection of the vagina. Therefore, if celiac disease is not accompanied by vaginal inflammation, do not advocate the application of local vaginal douche. Can celiac disease be cured At present, the most widely used method of treating celiac disease in China is physical therapy. It is often believed that physical therapy can cure celiac disease in one go. In fact, in the absence of a clear cause, no matter what kind of conservative treatment, it is impossible to completely cure celiac disease. Clinically, it is often encountered that after physical therapy treatment of cervical erosion, the erosion area becomes smooth (columnar epithelium is replaced by squamous epithelium), but after a period of time, cervical erosion reappears. Whether the application of microwave, ironing, laser or freezing methods, the principle is to destroy the columnar epithelium of the surface of the erosion, so that its necrosis, crusting off, the newborn squamous epithelium grows in, to achieve a “cure”. If the real cause of the disease is not removed, celiac disease may occur again. In recent years, the treatment of celiac disease in the academic world has some new ideas. When there is no pathogenic microbial infection, celiac disease can have no clinical symptoms, or only manifested as increased secretions, no treatment is required. (1)<30 years old, for simple, superficial erosion is mostly physiological changes, without special treatment. (2)>30 years old, or granular erosion, asymmetric erosion, with contact bleeding, cervical hardness is different, should be cervical lesion three-step screening, except cervical lesions. (3) Granular or papillary erosion should be treated if combined with inflammatory symptoms such as increased leukorrhea and vulvovaginal itching. In cases where cervical cancer is excluded, physiotherapy is mostly advocated. (4) Physiotherapy has more methods, but the treatment principle is the same and the efficacy is similar. The key is to grasp the correct indications, standardize the operation and pay attention to the treatment period. Does physiotherapy have any effect on pregnancy and labor in the future? Physical methods such as laser treatment may cause slight damage to the cervix, which may affect the dilatation of the cervix during labor and delivery in the future. It is best to go to the hospital for a checkup before you plan to get pregnant. If the celiac disease does not affect your pregnancy or is not associated with an acute infection, you can get pregnant first, and then undergo laser treatment after delivery. However, if your condition requires it, you should still follow your doctor’s advice and actively cooperate with the treatment. In principle, physical therapy only destroys a layer of cells on the surface of the cervix, and through damage repair, the columnar epithelial cells are transformed into squamous epithelial cells, thus treating cervical erosion, so physical therapy will not lead to narrowing of the cervical opening, not to mention infertility.