In life, there are many patients with cranial defects due to various reasons, and they are worried about the harm of cranial defects, such as whether they will be afraid of heat and what harm they will do to the brain. For the common concern of patients, cranial defects may have great harm, not only to the brain, but also in the whole body may show a series of discomfort symptoms, called “cranial defect syndrome”. The harm of cranial defect lies in the destruction of the integrity of the skull, the closure of the cranial cavity and the stability of the intracranial environment, which causes cerebrospinal fluid circulation and blood circulation disorders and affects the normal neurological function, resulting in a series of neurological symptoms. Some patients may show dizziness, headache, weakness of limbs, poor fine activities, weakened vision, emotional instability, irritability, etc. Therefore, patients with cranial defects should undergo cranial repair. Cranial repair is a common neurosurgical procedure. For skull repair, one is to choose the repair material with excellent performance, and the other is to require high surgical skills. There is a new type of special polymer material, polyether ether ketone (PEEK), which has excellent performance, and is not thermally conductive, so patients will not be afraid of heat or cold. The trend is to achieve anatomical integrity, functional integrity, and functional integrity. It can achieve the organic unity of anatomical integrity, functional perfection and aesthetic appearance, which has been recognized and praised by patients, and it is a better material for repairing patients with skull defects.