Cryptococcus is detected by culturing the fungus from the infected area, but the diagnosis needs to be made by combining auxiliary tests and clinical manifestations. Cryptococcus is detected by collecting and culturing secretions from the site of infection to see if cryptococcus is growing and multiplying. Cryptococcal infections may be located in the lungs, the skin, or the bloodstream. A sample is collected and incubated on a culture medium for a specific length of time to see if cryptococcal growth is present. If bacterial growth is present, cryptococcal infection is determined to be present in the sample. Specimen testing at the site of infection can help determine the presence of cryptococcal infection and identify the cryptococcal strain. However, in order to diagnose cryptococcal infection, a comprehensive diagnosis needs to be made in conjunction with the clinical symptoms or ancillary tests presented by the patient himself. The presence of significant skin inflammation, pain or elevated white blood cells, and imaging abnormalities can all be used to support the diagnosis. If cryptococcal infection is suspected, it is recommended to go to the hospital in time to carry out specimen culture to determine the specific type of infected bacteria, so as to carry out antibacterial treatment in time.