Penicillin belongs to the broad-spectrum anti-infective drugs frequently used in clinical practice, and has a certain therapeutic effect on Gram-negative bacilli and Gram-positive bacilli. The frequently used penicillins in pediatrics include amoxicillin, amoxicillin clavulanic acid potassium, flucloxacillin, cefadroxil, piperacillin, etc. Because children are relatively young and their liver and kidney functions are not well developed, the use of antibiotic drugs needs to have certain indications for medication, and the pathogens of infection can be clarified through laboratory tests such as blood routine, calcitoninogen, C-reactive protein, blood culture, etc., and then the drugs can be used symptomatically. At the same time, penicillin easily affects the liver and kidney function of children, so the course of use also needs to be controlled, and penicillin skin test needs to be done before use, and if there are allergic symptoms, it cannot be used.