The human body once a month blood transfusion does not produce blood is mainly caused by its own hematopoietic dysfunction. Hematopoietic dysfunction is caused by a variety of reasons of hematopoietic stem cell proliferation, differentiation disorders, or hematopoietic microenvironment abnormalities or destruction, resulting in anemia as the main manifestation of the disease. Commonly, there are aplastic anemia, pure red blood cell aplastic anemia, thalassemia, aplastic crisis and myelodysplastic syndrome. 1. Aplastic anemia: It is a disease in which the bone marrow hematopoietic tissue decreases due to physical, chemical, biological and some unknown reasons, causing hematopoietic failure. It is characterized by functional damage of hematopoietic stem cells or hematopoietic microenvironment, which leads to reduction of whole blood cells and progressive anemia, infection and bleeding. 2. Pure erythrocyte aplastic anemia: it refers to anemia with hematopoietic dysfunction of erythrocyte system in which the bone marrow has fewer or fewer pure erythrocytes due to the damage and failure of erythropoietic system. 3. Aplastic crisis: it refers to a transient severe anemia caused by temporary inhibition of bone marrow red blood system hematopoiesis that occurs suddenly due to certain causative factors in the process of chronic hereditary hemolytic anemia. 4. Thalassemia: congenital hereditary disease, caused by the impairment of bead protein production. 5. Myelodysplastic syndromes, etc.: due to abnormal bone marrow hematopoiesis, it can be accompanied by severe anemia, thrombocytopenia and other index abnormalities. The human body once a month blood transfusion does not produce blood may also have other reasons, it is recommended to go to the hospital in a timely manner, improve the examination to clarify the cause of the disease, under the guidance of the physician to give targeted treatment or treatment.