Causes of high alanine aminotransferase (ALT) and alanine aminotransferase (AST) may be due to physiological reasons such as staying up all night, exertion, etc., and usually do not require special treatment. They may also be caused by diseases such as hepatitis B, fatty liver, cirrhosis, etc. They can be treated by using medicines such as entecavir, fenofibrate, glycyrrhizic acid preparations, and surgery. 1. Physiological increase: staying up late, laboring. Physiological reasons such as drinking alcohol can lead to transient elevation of transaminases, which can recover by itself without special treatment. 2. Hepatitis B: Hepatitis B virus infection causes damage to the liver, which in turn causes the patient’s alanine aminotransferase and ghrelin aminotransferase to be high, and some antiviral drugs, such as entecavir, etc., can be used for treatment. 3. Fatty liver: patients with fatty liver also have high ALT and AST, which can be treated with medications such as fenofibrate. 4. Cirrhosis: Cirrhosis of the liver due to alcoholism, infection, etc. may also cause high ALT and AST. When the condition is mild, some antiviral drugs such as entecavir and anti-inflammatory drugs such as glycyrrhizic acid preparation can be used; when the condition is more serious, liver transplantation may be needed. If the test results of alanine aminotransferase (ALT) and aliquot aminotransferase (AST) are abnormal, it is recommended to consult a doctor for diagnosis and treatment.