The difference between Gui Fu Di Huang Wan and Yu Gui Wan lies in the composition, efficacy and main treatment. 1. Difference in composition and efficacy: Gui Fu Di Huang Wan is composed of Chinese yam, cinnamon, prepared epimedium, cornelian cherry, cooked di Huang, Poria and so on, and its efficacy is to warm and tonify the kidney yang (warming and replenishing the yang qi of the kidney). Right Angelica Pill is composed of Chinese yam, Radix Rehmanniae Praeparata, Radix Angelicae Sinensis, Semen Cuscutae, Rhizoma Polygonati Odorati, Radix Polygonati Odorati, Fructus Lycii, Radix Angelicae Corii Asini, and so on. Its effects are to warm and replenish Kidney-Yang, fill up the essence and stop spermatorrhea (to fill up the essence of the body and prevent spermatorrhea). 2. Difference in treatments: Gui Wei Di Huang Wan treats soreness and coldness of the waist and knees due to kidney yang deficiency (lack of yang qi in the kidneys), phlegm (pathological product of impaired metabolism of water and fluid), wheezing and coughing, dysuria (unsmooth urination), or reflux, and so on. Right Angelica Pill is used for treating dysphoria, coldness and soreness of the waist and knees, impotence and spermatorrhea, fear of coldness, and frequent urination caused by insufficiency of kidney yang (lack of yang in the kidneys) and failure of fire in the life gate (weakening of kidney yang in the organism, with a reduced function of warming and pushing the circulation of qi and blood). The adverse reactions and contraindications of Gui Fu Di Huang Wan and Yu Gui Wan are not known. The medicines should be used under the guidance of a doctor and not blindly on their own.