Recently, a relative suddenly called to say that he had a myocardial infarction, and I wondered if the coronary angiogram he had done in a hospital last year had only mild stenosis, and if it was an inflammatory reaction caused by atheromatous plaque rupture, resulting in coronary embolism. I went to the tertiary hospital where he was hospitalized and pulled out his medical records, which showed severe stenosis but no plaque, elevated troponin, and ST-segment elevation on the ECG, which was significantly relieved by the injection of nitroglycerin and isoptin. This is a special kind of coronary artery disease different from the general coronary artery disease, coronary spasm caused by —- variant angina, he has a particularly high rate of misdiagnosis and underdiagnosis, which sometimes leads to life-threatening. The coronary artery is the blood vessel that supplies blood to the heart itself, like the body’s engine, and he sometimes spasms like a muscle, for varying durations, sometimes causing ischemia and hypoxia in the heart and angina. variant angina is different from the usual coronary angina, which occurs mostly at rest, mostly in the latter part of the night and early morning. This is when the vagus nerve is excited and prone to spasm, these people are usually active instead of symptomatic, and cause the doctor to be suspicious. The active plate test and the Pansentine load test are also negative. The ST segment is elevated, not lowered, during the seizure. Ergonovine may induce it. Prolonged coronary spasm can lead to myocardial infarction or even sudden death. The clinical etiology is unclear. Physicians must not be paralyzed.