Not all patients with coronary artery disease need interventional therapy. In fact, the treatment of coronary heart disease is comprehensive, including drug therapy (basic therapy), interventional therapy and surgical treatment. Clinically, the appropriate treatment plan must be selected according to the patient’s specific condition and vascular lesion. For mild stenosis, stenosis with little effect on blood flow, or some less important small branch vascular lesions, only drug therapy is usually chosen, followed by regular follow-up and observation; implanting stents or performing balloon dilation at this time may do more harm than good. For patients with severe stenosis that cannot be treated with intervention or surgery, drug therapy is the only option. For patients with coronary artery disease who also have structural changes in the heart (e.g., combined valvular disease, obvious ventricular wall tumors after myocardial infarction, etc.), surgical treatment should be preferred to completely resolve these problems; interventional treatment can currently only address the vascular problems (mainly stenosis) and cannot help with structural changes in the heart. In addition, certain areas of the vasculature are very risky for interventional treatment and relatively less risky for surgical procedures, when surgical treatment should also be chosen. For these reasons, the best indications for intervention are patients with no structural changes in the heart, with severe stenosis and significant angina. Such patients will benefit most from interventional therapy. Fortunately, such patients make up the majority of patients in clinical practice. Intervention before myocardial infarction is more beneficial than intervention after myocardial infarction because the necrotic myocardium cannot be revived after myocardial necrosis, even if the blood vessels are unblocked. The purpose of interventional treatment during or after myocardial infarction is to reduce the amount of myocardial necrosis and to save the myocardium that is dying due to severe myocardial ischemia. Therefore, it is currently advocated that patients with acute myocardial infarction and unstable angina should be actively examined and treated as early as possible. Therefore, not all patients with coronary artery disease should receive interventional treatment, and not all patients with coronary artery disease can undergo interventional treatment.