If the patient has a sudden onset of crooked mouth and headache, it is more likely to be caused by cerebrovascular disease, which can be caused by cerebral infarction or cerebral hemorrhage resulting in central facial palsy manifesting as a crooked mouth, or headache due to infarction or hemorrhage. If the patient’s mouth is crooked and headache appears gradually, it may be caused by intracranial occupying lesions, primary tumors or metastases in the brain, which can also be diagnosed after CT and MRI examination. The clinical symptoms of crooked mouth and headache are also seen in some patients with peripheral facial neuritis, who develop peripheral facial palsy after catching a cold or flu, as well as headache due to flu. In the acute stage of peripheral facial palsy, the patient can be given treatment to reduce facial nerve edema and nerve nutrition.