Hypertension has a classification of blood pressure and a risk stratification, and hypertension in the very high risk group is the highest level inside the risk stratification of hypertension. The main aspects of how to treat hypertension in the very high risk group are: 1. general treatment, there can be low salt, low fat diet, weight control, weight loss, smoking cessation, alcohol cessation, appropriate exercise, maintain an optimistic state of mind, adequate sleep. 2. pharmacological treatment of hypertension, hypertension in the very high risk group, or advocate a smooth antihypertensive, the choice of long-acting agents combined antihypertensive, small doses to start individualized treatment program. Specifically to clinical drugs, there are five major clinical antihypertensive drugs, the more commonly used program is ACEI or ARB plus CCB, ACEI commonly used are Benazepril, Perindopril; ARB commonly used are Valsartan, Irbesartan, Crosartan; calcium antagonists is the so-called CCB, commonly used are Amlodipine, Nifedipine, Lercanidipine and so on. Benazepril 1 tablet plus amlodipine 1 tablet can be used for treatment first. Observe for 2 weeks-12 weeks with blood pressure monitoring, if the blood pressure slowly reaches the target value, referring to the target of 140/90mmHg or less within 60 years of age. If the target value is less than 150/90 mmHg or less for those over 60 years of age, continue to consolidate if this value is reached and continue to apply treatment with monitored blood pressure. If the target value is not reached, the drug dose can be increased to reach the target dose, or the frequency of the drug can be increased. If the target blood pressure is still not reached, an additional antihypertensive drug can be added. The third antihypertensive drug is usually chosen as a diuretic, either half a tablet of double gram or one tablet of indapamide combined with antihypertensive until the target value is reached, and the time window of observation is also 2 weeks-12 weeks.