If intermediate stage bile duct cancer is detected after liver and gallbladder surgery, one should improve the examination, such as abdominal ultrasound, abdominal enhanced CT, etc., and actively carry out surgical treatment, chemotherapy, radiotherapy and targeted therapy. If intermediate stage bile duct cancer is found after liver and gallbladder surgery, relevant examinations, such as abdominal ultrasound and abdominal CT, etc., should be improved actively, and then the most reasonable treatment plan should be formulated. 1. Surgery: Define the size and location of mid-stage cholangiocarcinoma and perform precise surgery to remove the cancerous tissues in order to improve the safety of surgery, which is also the most effective treatment method. 2. Radiotherapy and chemotherapy: radiotherapy and chemotherapy are more and more widely used in clinic as auxiliary treatments after surgical treatment. According to pathological type, staging and physical condition, a reasonable plan should be chosen, for example, gemcitabine combined with platinum (e.g., cisplatin) anticancer drugs can maximize the therapeutic effect. 3. Targeted therapy: targeted therapy can inhibit the growth of tumor blood vessels to achieve the purpose of targeted therapy, which is used to make up for the insufficiency of surgery, radiotherapy and chemotherapy to a certain extent, such as lenvatinib, but it should be chosen individually according to the actual situation. Hepatobiliary surgery found mid-stage cholangiocarcinoma should clarify the specific situation as early as possible, and choose appropriate treatment methods under the guidance of physicians to avoid the development of the disease.