Hand peeling may be caused by physiological factors, such as environmental dryness, etc. This cause of hand peeling is not related to vitamin deficiency. Hand peeling may also be caused by pathological factors, such as sweating herpes, tinea cruris, niacin deficiency, etc. Among them, niacin deficiency is considered to be related to the body’s lack of vitamin B3, while the other diseases mentioned above do not have much to do with vitamin deficiency. 1. Physiological factors Lack of sebaceous glands in palmoplantar and other parts of the body can lead to peeling of the hands if hands are washed for a long time with alkaline and irritating detergents, and this condition is usually not related to vitamin deficiency. 2. Pathologic factors: (1) Sweat herpes: the main symptom is the appearance of blisters on the hands and feet, rupture and drying will appear peeling skin. The cause of its formation may be related to allergies, infections and mental factors, usually not related to vitamin deficiency. (2) Ringworm: the disease is mainly related to the infection of dermatophytes such as Trichophyton spp. and Microsporum spp. Patients will have hyperkeratotic skin lesions on the hands, such as desquamation, dryness, blisters, etc., which are usually not related to vitamin deficiency. (3) Niacin deficiency: the cause of the disease is usually related to the lack of vitamin B, the body’s niacin metabolism abnormalities and other factors, the patient’s skin will appear lesions, especially sunburned areas may appear erythema, edema, and then the skin can be rough, flaking and other symptoms, commonly found on the back of the hands, forearms, neck and other places. Niacin deficiency is mostly related to vitamin deficiency, which may lead to hand peeling, but it is not the only cause of hand peeling, other diseases may also lead to the symptoms. Therefore, it is recommended that patients rule out physiological factors and then seek medical examination to clarify the cause.