Vitamin A cream rub face, face darkening may be daytime use and do not pay attention to sun protection caused. Retinoic acid cream is a keratolytic agent, the drug has photosensitivity, sunlight can aggravate the stimulation of retinoic acid on the skin leading to the decomposition of retinoic acid, so the drug is most suitable for application in the evening and before going to bed, the treatment process should be avoided sun exposure, or the use of light shielding measures. Failure to use light shielding measures during the use of retinoic acid cream may result in hyperpigmentation, which can lead to darkening of the face. The use of the drug should also be noted that it is contraindicated in women during pregnancy; contraindicated in breastfeeding; contraindicated in those who are allergic to any of the components of the product; and contraindicated in the eyes. And some patients may experience irritation such as burning sensation and peeling of the skin after use. In conclusion, if you find that the use of retinoic acid cream skin more and more smear black, can be in the physician’s guidance of intermittent use of drugs or suspension of the use of drugs; if the symptoms have not improved, but also need to consult a doctor to find out whether other causes.