Nephritis generally refers to glomerulonephritis, lower limb swelling needs etiological treatment, combined with general treatment, diuretics, glucocorticoids and immunosuppressants, antihypertension and other treatments, if necessary, infection control, anticoagulation, lipid-lowering, etc., the use of medication in accordance with medical advice. Nephritis is categorized into primary glomerulonephritis, secondary glomerulonephritis, etc. Swelling of the lower limbs often occurs and needs active treatment. 1. Treatment of etiology: especially secondary glomerulonephritis, such as lupus nephritis, allergic purpura nephritis, etc., need to actively correct the cause of the disease, the treatment of systemic lupus erythematosus, allergic purpura, etc., after the primary disease improves, the swelling of the lower limbs also improved significantly. 2. General treatment: lower limb edema patients should strictly control the salt intake, 2-3g per day, and supplement protein according to the renal function. 3. Diuretics: commonly used tabs diuretics, such as furosemide, torasemide, etc., the effect is not obvious, plus the use of potassium-trapping diuretics, such as spironolactone, severe edema or the ineffectiveness of the above drugs, osmotic diuretics such as mannitol can be used. 4. Glucocorticoids and immunosuppressants: commonly used drugs include prednisone, cyclophosphamide, cyclosporine, leflunomide, etc. 5. Antihypertensive drugs: nephritis with lower limb edema patients are often accompanied by hypertension, need to actively control blood pressure, can choose ACEI (such as captopril, enalapril) or ARB class (such as valsartan, candesartan), if necessary, choose the compound preparation, such as timosartan hydrochlorothiazide tablets. After the emergence of nephritis lower limb edema, you need to consult the doctor in time, strictly follow the medical prescription of medication, if necessary, you also need to actively anti-infection, anticoagulation, lipid lowering and other symptomatic treatment.