The signs and symptoms of insulin resistance may include acanthosis nigricans, preprandial hypoglycemia, etc. Some patients may also have no obvious clinical manifestations. It is recommended that patients with insulin resistance should seek prompt medical attention. Insulin resistance is mainly caused by the decrease of insulin sensitivity of the body, in some cases, patients with insulin resistance may not have obvious clinical manifestations, some patients may have symptoms such as acanthosis nigricans, preprandial hypoglycemia and so on. Echinococcosis is the characteristic skin damage of insulin resistance, which can be manifested as papillomatous and velvety melanin deposits and hyperkeratosis in the folds and neck; preprandial hypoglycemia is often seen when patients do not eat on time, and may have symptoms such as panic, cold sweat, and shaking hands. Patients with manifestations related to insulin resistance should go to the hospital and ask the doctor to make a judgment.