High thyroid peroxidase antibody may be caused by certain autoimmune thyroid diseases, such as Hashimoto’s thyroiditis, Graves’ disease, postpartum thyroiditis, atrophic thyroiditis, etc. In addition, certain autoimmune diseases, such as rheumatoid disease, systemic lupus erythematosus, etc., may also lead to high thyroid peroxidase antibody. Serum thyroid peroxidase antibody is usually less than 60IU/ml, due to the different testing methods and reagents, the reference indexes of each hospital are different and need to be analyzed specifically. If the test finds that the serum thyroid peroxidase antibody level is abnormally high, it is necessary to pay attention to it, improve the relevant examination, clarify the condition under the guidance of professional physicians and actively treat it.