Aspirin and sodium bicarbonate can be taken at the same time without serious adverse effects on the body. However, sodium bicarbonate will affect the absorption of aspirin. Because aspirin is acetylsalicylic acid, which is acidic, and sodium bicarbonate is alkaline, when the two are taken at the same time, it will lead to an increase in the dissociative form of aspirin and a decrease in absorption. Aspirin is an antipyretic and analgesic mainly used for the treatment of mild to moderate pain, but also for cold and fever fever antipyretic treatment, in addition, aspirin also inhibits the role of platelet aggregation, can be used for myocardial infarction and thrombotic disease prophylaxis. Sodium bicarbonate is an alkaline drug, mainly used to neutralize excessive stomach acid, but also can alkalize the urine, promote the prevention of urate crystal deposition and the formation of kidney stones. Aspirin and sodium bicarbonate do not overlap or conflict in terms of mechanism of action and indications, nor do they cause aggravation of adverse reactions, therefore, they can be taken at the same time. If there is any discomfort, consult a doctor and follow the doctor’s instructions.